Ecklonia Cava References

The Health-Care Survivor Provides More Than 300 Scientific References For Ecklonia Cava — A Treasure-Trove Of Health, From The Sea Of Japan
  • Ahn G, Amagai Y, Matsuda A, Kang SM, Lee W, Jung K, Oida K, Jang H, Ishizaka S, Matsuda K, Jeon YJ, Jee Y, Matsuda H, Tanaka A. Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction. Exp Dermatol. 2015 Jul 21. doi: 10.1111/exd.12814. [Epub ahead of print] PubMed PMID: 26194398.
  • Ahn G, Amagai Y, Matsuda A, Kang SM, Lee W, Jung K, Oida K, Jang H, Ishizaka S, Matsuda K, Jeon YJ, Jee Y, Matsuda H, Tanaka A. Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction. Exp Dermatol. 2015 Jul . PMID: 26194398.
  • Ahn G, Bing SJ, Kang SM, Lee WW, Lee SH, Matsuda H, Tanaka A, Cho IH, Jeon YJ, Jee Y. The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava. Biochim Biophys Acta. 2013 Mar;1830(3):2820-9. PubMed PMID: 23262141.
  • Ahn G, Bing SJ, Kang SM, Lee WW, Lee SH, Matsuda H, Tanaka A, Cho IH, Jeon YJ, Jee Y. The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava. Biochim Biophys Acta. 2013 Mar;1830(3) 2820-2829. doi:10.1016/j.bbagen.2012.12.008. PMID: 23262141.
  • Ahn G, Hwang I, Park E, Kim J, Jeon YJ, Lee J, Park JW, Jee Y. Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes. Mar Biotechnol (NY). 2008 May-Jun;10(3):278-89. doi:10.1007/s10126-007-9062-9. Epub 2008 Jan 3. PubMed PMID: 18172723.
  • Ahn G, Hwang I, Park E, Kim J, Jeon YJ, Lee J, Park JW, Jee Y. Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes. Mar Biotechnol (NY). 2008 May-Jun;10(3) 278-289. doi:10.1007/s10126-007-9062-9. PMID: 18172723.
  • Ahn G, Park E, Lee WW, Hyun JW, Lee KW, Shin T, Jeon YJ, Jee Y. Enzymatic extract from Ecklonia cava induces the activation of lymphocytes by IL-2 production through the classical NF-κB pathway. Mar Biotechnol (NY). 2011 Feb;13(1):66-73. doi: 10.1007/s10126-010-9270-6. Epub 2010 May 18. PubMed PMID: 20480199.
  • Ahn G, Park E, Lee WW, Hyun JW, Lee KW, Shin T, Jeon YJ, Jee Y. Enzymatic extract from Ecklonia cava induces the activation of lymphocytes by IL-2 production through the classical NF-κB pathway. Mar Biotechnol (NY). 2011 Feb;13(1) 66-73. doi:10.1007/s10126-010-9270-6. PMID: 20480199.
  • Ahn Gin-Nae, Kim Kil-Nam, Cha Seon-Heui, Song Choon-Bok, Lee Jehee, Heo Moon-Soo, Yeo In-Kyu, Lee Nam-Ho, Jee Young-Heun, Kim Jin-Soo, Heu Min-Soo, Jeon You-Jin. Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H₂O₂-mediated DNA damage Eur Food Res Technol. 2007 Nov;226(1-2) 71-79. doi:10.1007/s00217-006-0510-y. AGR:IND43952846.
  • Ahn JH, Yang YI, Lee KT, Choi JH. Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth. J Cancer Res Clin Oncol. 2015 Feb;141(2):255-68. doi: 10.1007/s00432-014-1819-8. Epub 2014 Sep 13. PubMed PMID: 25216701.
  • Ahn JH, Yang YI, Lee KT, Choi JH. Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth. J Cancer Res Clin Oncol. 2015 Feb;141(2) 255-268. doi:10.1007/s00432-014-1819-8. PMID: 25216701.
  • Ahn MJ, Yoon KD, Min SY, Lee JS, Kim JH, Kim TG, Kim SH, Kim NG, Huh H, Kim J. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biol Pharm Bull. 2004 Apr;27(4):544-7. PubMed PMID: 15056863.
  • Ahn MJ, Yoon KD, Min SY, Lee JS, Kim JH, Kim TG, Kim SH, Kim NG, Huh H, Kim J. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biol Pharm Bull. 2004 Apr;27(4) 544-547. doi:10.1248/bpb.27.544. PMID: 15056863.
  • Ale MT, Mikkelsen JD, Meyer AS. Important determinants for fucoidan bioactivity: a critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds. Mar Drugs. 2011;9(10) 2106-2130. doi:10.3390/md9102106. PMID: 22073012; PMCID: PMC3210621.
  • Artan M, Li Y, Karadeniz F, Lee SH, Kim MM, Kim SK. Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava. Bioorg Med Chem. 2008 Sep 1;16(17):7921-6. doi: 10.1016/j.bmc.2008.07.078. Epub 2008 Jul 29. PubMed PMID: 18693022.
  • Artan M, Li Y, Karadeniz F, Lee SH, Kim MM, Kim SK. Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava. Bioorg Med Chem. 2008 Sep;16(17) 7921-7926. doi:10.1016/j.bmc.2008.07.078. PMID: 18693022.
  • Atamna H, Mackey J, Dhahbi JM. Mitochondrial pharmacology: electron transport chain bypass as strategies to treat mitochondrial dysfunction. Biofactors. 2012 Mar-Apr;38(2) 158-166. doi:10.1002/biof.197. PMID: 22419586; PMCID: PMC4299858.
  • Athukorala Y, Kim KN, Jeon YJ. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem Toxicol. 2006 Jul;44(7):1065-74. Epub 2006 Mar 3. PubMed PMID: 16516367.
  • Athukorala Y, Kim KN, Jeon YJ. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem Toxicol. 2006 Jul;44(7) 1065-1074. doi:10.1016/j.fct.2006.01.011. PMID: 16516367.
  • Bak SS, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK. Ecklonia cava promotes hair growth. Clin Exp Dermatol. 2013 Dec;38(8):904-10. doi: 10.1111/ced.12120. PubMed PMID: 24252083.
  • Bak SS, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK. Ecklonia cava promotes hair growth. Clin Exp Dermatol. 2013 Dec;38(8) 904-910. doi:10.1111/ced.12120. PMID: 24252083.
  • Balboa EM, Moure A, Domínguez H. Valorization of Sargassum muticum Biomass According to the Biorefinery Concept. Mar Drugs. 2015 Jun;13(6) 3745-3760. doi:10.3390/md13063745. PMID: 26110896; PMCID: PMC4483654.
  • Barbosa M, Valentão P, Andrade PB. Bioactive compounds from macroalgae in the new millennium: implications for neurodegenerative diseases. Mar Drugs. 2014 Sep;12(9) 4934-4972. doi:10.3390/md12094934. PMID: 25257784; PMCID: PMC4178484.
  • Bentley DJ, Ackerman J, Clifford T, Slattery KS. Acute and Chronic Effects of Antioxidant Supplementation on Exercise Performance. PMID: 26065084.
  • Bhatnagar I, Kim SK. Immense essence of excellence: marine microbial bioactive compounds. Mar Drugs. 2010;8(10) 2673-2701. doi:10.3390/md8102673. PMID: 21116414; PMCID: PMC2993000.
  • Bhatnagar I, Kim SK. Marine antitumor drugs: status, shortfalls and strategies. Mar Drugs. 2010;8(10) 2702-2720. doi:10.3390/md8102702. PMID: 21116415; PMCID: PMC2993001.
  • Cao RA, Lee Y, You S. Water soluble sulfated-fucans with immune-enhancing properties from Ecklonia cava. Int J Biol Macromol. 2014 Jun;67:303-11. doi: 10.1016/j.ijbiomac.2014.03.019. Epub 2014 Mar 21. PubMed PMID: 24661888.
  • Cao RA, Lee Y, You S. Water soluble sulfated-fucans with immune-enhancing properties from Ecklonia cava. Int J Biol Macromol. 2014 Jun;67 303-311. doi:10.1016/j.ijbiomac.2014.03.019. PMID: 24661888.
  • Cha SH, Ko CI, Kim D, Jeon YJ. Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio). Vet Dermatol. 2012 Feb;23(1):51-6, e12. doi: 10.1111/j.1365-3164.2011.01009.x. Epub 2011 Nov 1. PubMed PMID: 22040269.
  • Cha SH, Ko CI, Kim D, Jeon YJ. Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio). Vet Dermatol. 2012 Feb;23(1) 51-6, e12. doi:10.1111/j.1365-3164.2011.01009.x. PMID: 22040269.
  • Cha SH, Ko SC, Kim D, Jeon YJ. Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish. J Dermatol. 2011 Apr;38(4):354-63. PubMed PMID: 21544943.
  • Cha SH, Ko SC, Kim D, Jeon YJ. Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish. J Dermatol. 2011 Apr;38(4) 354-363. doi:10.1111/j.1346-8138.2010.00983.x. PMID: 21544943.
  • Chan CH, Ngoh GC, Yusoff R. A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms. Pharmacogn Rev. 2012 Jan;6(11) 22-28. doi:10.4103/0973-7847.95854. PMID: 22654401; PMCID: PMC3358964.
  • Cheng CW, Chang WL, Chang LC, Wu CC, Lin YF, Chen JS. Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model. Evid Based Complement Alternat Med. 2012;2012 161235. doi:10.1155/2012/161235. PMID: 22844329; PMCID: PMC3403610.
  • Chikaraishi Y, Steffan SA, Ogawa NO, Ishikawa NF, Sasaki Y, Tsuchiya M, Ohkouchi N. High-resolution food webs based on nitrogen isotopic composition of amino acids. Ecol Evol. 2014 Jun;4(12) 2423-2449. doi:10.1002/ece3.1103. PMID: 25360278; PMCID: PMC4203290.
  • Cho S, Han D, Kim SB, Yoon M, Yang H, Jin YH, Jo J, Yong H, Lee SH, Jeon YJ, Shimizu M. Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed. Biosci Biotechnol Biochem. 2012;76(1):163-8. Epub 2012 Jan 7. PubMed PMID: 22232271.
  • Cho S, Han D, Kim SB, Yoon M, Yang H, Jin YH, Jo J, Yong H, Lee SH, Jeon YJ, Shimizu M. Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed. Biosci Biotechnol Biochem. 2012;76(1) 163-168. doi:10.1271/bbb.110702. PMID: 22232271.
  • Cho S, Yang H, Jeon YJ, Lee CJ, Jin YH, Baek NI, Kim D, Kang SM, Yoon M, Yong H, Shimizu M, Han D. Phlorotannins of the edible brown seaweed Ecklonia cava Kjellman induce sleep via positive allosteric modulation of gamma-aminobutyric acid type A–benzodiazepine receptor: A novel neurological activity of seaweed polyphenols Food Chem. 2012 Jun;132(3) 1133-1142. doi:10.1016/j.foodchem.2011.08.040. AGR:IND44654477.
  • Choi BW, Lee HS, Shin HC, Lee BH. Multifunctional activity of polyphenolic compounds associated with a potential for Alzheimer’s disease therapy from Ecklonia cava. Phytother Res. 2015 Apr;29(4):549-53. doi: 10.1002/ptr.5282. Epub 2015 Jan 14. PubMed PMID: 25640212.
  • Choi BW, Lee HS, Shin HC, Lee BH. Multifunctional activity of polyphenolic compounds associated with a potential for Alzheimer’s disease therapy from Ecklonia cava. Phytother Res. 2015 Apr;29(4) 549-553. doi:10.1002/ptr.5282. PMID: 25640212.
  • Choi HJ, Park JH, Lee BH, Chee HY, Lee KB, Oh SM. Suppression of NF-κB by dieckol extracted from Ecklonia cava negatively regulates LPS induction of inducible nitric oxide synthase gene. Appl Biochem Biotechnol. 2014 Jun;173(4):957-67. doi: 10.1007/s12010-014-0910-6. Epub 2014 Apr 18. PubMed PMID: 24744158.
  • Choi HJ, Park JH, Lee BH, Chee HY, Lee KB, Oh SM. Suppression of NF-κB by dieckol extracted from Ecklonia cava negatively regulates LPS induction of inducible nitric oxide synthase gene. Appl Biochem Biotechnol. 2014 Jun;173(4) 957-967. doi:10.1007/s12010-014-0910-6. PMID: 24744158.
  • Choi HS, Jeon HJ, Lee OH, Lee BY. Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell-cycle arrest and AMPKα activation. Mol Nutr Food Res. 2015 Aug;59(8):1458-71. doi: 10.1002/mnfr.201500021. Epub 2015 May 28. PubMed PMID: 25944759.
  • Choi HS, Jeon HJ, Lee OH, Lee BY. Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell-cycle arrest and AMPKα activation. Mol Nutr Food Res. 2015 Aug;59(8) 1458-1471. doi:10.1002/mnfr.201500021. PMID: 25944759.
  • Choi JG, Kang OH, Brice OO, Lee YS, Chae HS, Oh YC, Sohn DH, Park H, Choi HG, Kim SG, Shin DW, Kwon DY. Antibacterial activity of Ecklonia cava against methicillin-resistant Staphylococcus aureus and Salmonella spp. Foodborne Pathog Dis. 2010 Apr;7(4):435-41. doi: 10.1089/fpd.2009.0434. PubMed PMID: 20001325.
  • Choi JG, Kang OH, Brice OO, Lee YS, Chae HS, Oh YC, Sohn DH, Park H, Choi HG, Kim SG, Shin DW, Kwon DY. Antibacterial activity of Ecklonia cava against methicillin-resistant Staphylococcus aureus and Salmonella spp. Foodborne Pathog Dis. 2010 Apr;7(4) 435-441. doi:10.1089/fpd.2009.0434. PMID: 20001325.
  • Choi JS, Bae HJ, Kim SJ, Choi IS. In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes. J Environ Biol. 2011 May;32(3):313-8. PubMed PMID: 22167943.
  • Choi JS, Bae HJ, Kim SJ, Choi IS. In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes. J Environ Biol. 2011 May;32(3) 313-318. PMID: 22167943.
  • Chowdhury MT, Bangoura I, Kang JY, Cho JY, Joo J, Choi YS, Hwang DS, Hong YK. Comparison of Ecklonia cava, Ecklonia stolonifera and Eisenia bicyclis for phlorotannin extraction. J Environ Biol. 2014 Jul;35(4):713-9. PubMed PMID: 25004758.
  • Chowdhury MT, Bangoura I, Kang JY, Cho JY, Joo J, Choi YS, Hwang DS, Hong YK. Comparison of Ecklonia cava, Ecklonia stolonifera and Eisenia bicyclis for phlorotannin extraction. J Environ Biol. 2014 Jul;35(4) 713-719. PMID: 25004758.
  • Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY. Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways. Korean J Physiol Pharmacol. 2015 May;19(3):219-28. doi: 10.4196/kjpp.2015.19.3.219. Epub 2015 Apr 30. PubMed PMID: 25954126; PubMed Central PMCID: PMC4422961.
  • Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY. Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways. Korean J Physiol Pharmacol. 2015 May;19(3) 219-228. doi:10.4196/kjpp.2015.19.3.219. PMID: 25954126; PMCID: PMC4422961.
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  • El Gamal AA. Biological importance of marine algae. Saudi Pharmaceutical Journal : SPJ. 2010 Jan;18(1) 1-25. doi:10.1016/j.jsps.2009.12.001. PMID: 23960716; PMCID: PMC3731014.
  • Eo H, Jeon YJ, Lee M, Lim Y. Brown Alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of AMPK and SIRT1 in high-fat diet-induced obese mice. J Agric Food Chem. 2015 Jan 14;63(1):349-59. PubMed PMID: 25479240.
  • Eo H, Jeon YJ, Lee M, Lim Y. Brown Alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of AMPK and SIRT1 in high-fat diet-induced obese mice. J Agric Food Chem. 2015 Jan;63(1) 349-359. doi:10.1021/jf502830b. PMID: 25479240.
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  • Ha D, Bing SJ, Cho J, Ahn G, Kim DS, Al-Amin M, Park SJ, Jee Y. Phloroglucinol protects small intestines of mice from ionizing radiation by regulating apoptosis-related molecules: a comparative immunohistochemical study. J Histochem Cytochem. 2013 Jan;61(1) 63-74. doi:10.1369/0022155412468426. PMID: 23117934; PMCID: PMC3534317.
  • Heffernan N, Brunton NP, FitzGerald RJ, Smyth TJ. Profiling of the molecular weight and structural isomer abundance of macroalgae-derived phlorotannins. Mar Drugs. 2015 Jan;13(1) 509-528. doi:10.3390/md13010509. PMID: 25603345; PMCID: PMC4306949.
  • Heo SJ, Ko SC, Cha SH, Kang DH, Park HS, Choi YU, Kim D, Jung WK, Jeon YJ. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol In Vitro. 2009 Sep;23(6):1123-30. doi: 10.1016/j.tiv.2009.05.013. Epub 2009 May 31. PubMed PMID: 19490939.
  • Heo SJ, Ko SC, Cha SH, Kang DH, Park HS, Choi YU, Kim D, Jung WK, Jeon YJ. Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol In Vitro. 2009 Sep;23(6) 1123-1130. doi:10.1016/j.tiv.2009.05.013. PMID: 19490939.
  • Heo SJ, Park PJ, Park EJ, Kim SK, Jeon YJ. Antioxidant activity of enzymatic extracts from a brown seaweed Ecklonia cava by electron spin resonance spectrometry and comet assay. Eur Food Res Technol. 2005 Jul;221(1-2) 41-47. doi:10.1007/s00217-005-1187-3. AGR:IND43790334.
  • Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, Affan A, Yoon KT, Choi YU, Park SC, Han S, Qian ZJ, Jung WK, Choi IW. Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes. Environ Toxicol Pharmacol. 2012 Nov;34(3):926-34. doi: 10.1016/j.etap.2012.08.003. Epub 2012 Aug 30. PubMed PMID: 22999063.
  • Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, Affan A, Yoon KT, Choi YU, Park SC, Han S, Qian ZJ, Jung WK, Choi IW. Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes. Environ Toxicol Pharmacol. 2012 Nov;34(3) 926-934. doi:10.1016/j.etap.2012.08.003. PMID: 22999063.
  • Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol Pharm Bull. 2006 Aug;29(8):1735-9. PubMed PMID: 16880634.
  • Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol Pharm Bull. 2006 Aug;29(8) 1735-1739. doi:10.1248/bpb.29.1735. PMID: 16880634.
  • Jung HA, Kim JI, Choung SY, Choi JS. Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. J Pharm Pharmacol. 2014 Aug;66(8):1180-8. doi: 10.1111/jphp.12241. Epub 2014 Mar 13. PubMed PMID: 24628384.
  • Jung HA, Kim JI, Choung SY, Choi JS. Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. J Pharm Pharmacol. 2014 Aug;66(8) 1180-1188. doi:10.1111/jphp.12241. PMID: 24628384.
  • Jung WK, Ahn YW, Lee SH, Choi YH, Kim SK, Yea SS, Choi I, Park SG, Seo SK, Lee SW, Choi IW. Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kappaB pathways. Food Chem Toxicol. 2009 Feb;47(2):410-7. doi: 10.1016/j.fct.2008.11.041. Epub 2008 Dec 11. PubMed PMID: 19111593.
  • Jung WK, Ahn YW, Lee SH, Choi YH, Kim SK, Yea SS, Choi I, Park SG, Seo SK, Lee SW, Choi IW. Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kappaB pathways. Food Chem Toxicol. 2009 Feb;47(2) 410-417. doi:10.1016/j.fct.2008.11.041. PMID: 19111593.
  • Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, Choi IW. Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells. J Agric Food Chem. 2009 May 27;57(10):4439-46. doi: 10.1021/jf9003913. Epub 2009 May 1. PubMed PMID: 19408937.
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  • Kalimuthu S, Se-Kwon K. Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds. Int J Mol Sci. 2013;14(2) 2334-2354. doi:10.3390/ijms14022334. PMID: 23348928; PMCID: PMC3587990.
  • Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways. Food Chem Toxicol. 2010 Feb;48(2):509-16. doi: 10.1016/j.fct.2009.11.004. Epub 2009 Nov 11. PubMed PMID: 19913068.
  • Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways. Food Chem Toxicol. 2010 Feb;48(2) 509-516. doi:10.1016/j.fct.2009.11.004. PMID: 19913068.
  • Kang IJ, Jang BG, In S, Choi B, Kim M, Kim MJ. Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity. Neurotoxicology. 2013 Jan;34:16-24. doi: 10.1016/j.neuro.2012.09.013. Epub 2012 Oct 4. PubMed PMID: 23041113.
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